Things That We Should Know About Pulmonary Arterial Hypertension

High blood pressure, commonly known as hypertension, is a common medical condition that about one in three adult American citizens has. However, pulmonary arterial hypertension is a rare and much more fatal medical condition. If someone is suffering from hypertension, the blood flow against the artery’s sides becomes too strong, imposing the risk of stroke or heart attack.

Several medical treatments available in today’s advanced technological world bring the ray of hope among the people having this condition. You can also click here to check the rapidly progressing clinical research trials for the optimal solution to this medical condition. In this guide, we discuss everything you need to know about pulmonary arterial hypertension in a concise, precise and understandable way. So, let’s dig in.

Pulmonary Arterial Hypertension: What Is It?

PAH or Pulmonary arterial hypertension is a form of high-blood pressure condition occurring in the lungs. This medical condition can be triggered due to several factors like chronic obstructive pulmonary disease (COPD) or sleep apnea.

This condition happens when the artery walls in the right side of your heart tighten and narrow down. This is why the pressure in the lungs increases, causing symptoms like shortness of breath and fatigue. If you undergo the correct diagnosis at the right time, you will reduce the chances of effects. However, there is no cure for this medical condition to date.

Pulmonary Arterial Hypertension: 5 Things You Must Know

Here is a brief yet informative section about four crucial things about pulmonary arterial hypertension (PAH).

1. Unknown Causes, But Physiological Changes Can Be The Key To Its Development

If the blood pressure that is leaving your right-sided heart arteries measures at 25 mmHg or higher, you will need a diagnosis for PAH. The exact reason that kicks off this medical condition is still unknown to all, but ongoing studies have found out how it progresses.

Experts from Global Medical Affairs say that PAH development starts from the constriction of the artery vessels that leads to the remodelling of the vessel wall. As the vessel wall thickens, the lumens, the space where our blood flows, becomes smaller and increases the pressure. 

2. Four Types of PAH

Most types of the PAH have no cause or precipitating factor, considering them all to be idiopathic. Studies show that about 6% of PAH cases are hereditary. The mutation in protein receptors, which affects tissue growth, causes this inheritance of the disease.

Carrying the genes doesn’t necessarily mean that you will develop PAH, but the chances are high as you become vulnerable to the triggering aspects.

PAH can also be drug-induced. Fen-Phen, which is fenfluramine and phentermine, are the two most common weight-loss medications that cause PAH. However, its supply has been restricted from 1970 till today’s market.

Finally, PAH is also caused by associative cases when a person already has pre-existing medical conditions like congenital heart disease, HIV, or scleroderma.

So, the four types for this medical condition are: idiopathic, hereditary, drug-induced and associative.

3. Women Gets More Affected BY PAH Than Men

According to the PAH Association, the PAH types: hereditary and idiopathic, are most common among women compared to men. You will find that PAH is primarily diagnosed in women aged between 30-60 years.

The exact reason why women are more susceptible to this disease is currently unknown, but some assumptions and theories suggest the involvement of estrogen as the cause. Estrogen, along with hormonal changes during pregnancy and autoimmune diseases, can be some prevalent factors associated with the higher vulnerability of women to PAH.

4. Effective Solution To Manage This Disease

  • If an individual is diagnosed with PAH, they have to start taking the medicated drugs combination to trigger the two different pathways, which is the biological mechanism of your body.
  • You have to start with one drug first and then shift to the second one within six months. The latest studies suggest that targeting three pathways at once will give better results for diagnosing this medical condition.
  • There is no exact cure, but the prognosis has become much better and advanced today. The median survival for people with PAH has increased from 2.5 years to 7-10 years and, in some cases, even 20 years.

Final Thoughts

So, get the best use of this comprehensive guide to having in-depth insight on pulmonary arterial hypertension. Ensure to do more research and add it to your knowledge.

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